Actually, Effexor and Pristiq are related but Pristiq is a structurally novel compound. They have the same active metobolite (which is thought to have the beneficial effects) but Pristiq has succinate salt added to it which allows for a predictable concentration of the medication. What all this means is that most patients will be able to stay at the starting dose of 50 mg with very good results. There have been very low incidences of side effects, little to no weight gain and sexual side effecfts don't seem to be an issue either.
The patent on effexor xr is good until 2010 and Pristiq is actually less expensive than effexor xr with a great co-pay program and every improving formulary coverage.
Some patients my be fine staying on Effexor XR but for anyone initiating therapy or someone who experience side effects Pristiq is a really good option. I know, I switch from 150 Effexor to 50 Pristiq and haven't felt this good in years!
I was on Effexor xr for 6 years, taking between 225 and 375 mgs a day. The only side effects I ever had were dry mouth and constipation. It worked better for me than any other antidepressant I had ever tried.
7 weeks ago my doctor put me on the 'New Effexor', Pristiq. After taking it for 3 weeks, I was so emotional, I cried over everything. My doctor told me to take two tabs instead of the one. At the end of a week, I called him again. I wasn't crying anymore, but was so aggitated and restless, I was miserable. I've been taking one and a half tabs for 4 days, I'm crying again, but, also, still aggitated and restless.
Effexor never did these things to me, so I don't see how they can be so close together chemically. I'm not taking any tonight, or any other night.
I'm sure it doesn't effect everyone that way.
My doctor swears by pristiq. I have been taking effexor for a couple of years (150 mg currently). My girlfriend was sick of the side effects so I decided to give it a try. The physician's assistant said it was fine to switch from one to another. BAD MOVE. ANYONE TELLING YOU THAT YOU CAN DO THIS IS LYING OR IGNORANT. I HAD A TOTAL MELTDOWN WITHIN FOUR DAYS. WANTED TO KILL MYSELF...ENDED UP IN A CLOSET CRYING FOR NO APPARENT REASON. I EVEN PISSED THE BED. I'M A 39 YEAR OLD MAN FOR HEAVEN'S SAKE. DO NOT GO FROM ONE TO THE OTHER HASTILY. There is a way to do it safely. It involves coming off the effexor slowly while introducing Pristiq simultaneously. I'm not a doctor so I'm not going to say how to do it. Don't rely on a physician's assistant to tell you how to take medication...get it from a real MD.
I am a 32 y.o. woman, who is single. Effexor Xr @ 300mg a day KILLED my libido. Since properly weaning myself off of Effex-no pun intended, and switch 2 Pristiq, I have some semblance of an actual sex drive. Not having one at my age doesn't do much for my depression or self-esteem. But, I also have way less side effects too! It has worked for me in the 6 mo that I have been taking 100mg, 50 mg did not fully help with my severe depression, anxiety/panic disorder, Lupus, Fibromyalgia & lethargy just to name a few...Ha ha ha! What works for one or some doesn't always mean that it will work for others. That law applies to most everything we do. I have tried literally countless anti-depressants and have NEVER experience such a good response than the one I have from Pristiq. Remember, u are your own health care advocate, not the doctors. So, though it may be literally h#ll to keep trying and failing then add the insult of going off these drugs, in the end, it may just be worth it. I know, I've been battling this for 12 yrs. Keep your chin up and if your anti isn't working, keep trying. I really believe that there is something out there for everyone, that's why the drug companies keep developing new drugs, not everyone responds the same. We're all genetically different; just like some people can eat eggs, dairy and peanuts while other cannot. Keep trying you may be suprised!
I have tried just two antidepresants in my whole life. First one, was Lexapro for 3 month, and a month ago my Doc. put me on PRISTIQ. Even I have been depressed for many years (crying for no reason, etc) it was not to the point of taking antidepresants. Until my personal trainer gave me (Phen Phen) from his point of view to cut down my food cravings, but instead this crap sent me to the hospital after (10 days) taking 1/2 pill daily!.. Anyways I ended up with PANICK ATACKS!! It was a nightmare for 6 whole month! I was getting up to 170 beats per minute (arrithmea) and my blood presure went up very high. I felt dying.. Since my story it is kind of long I'm going to summerize by saying, EVERY BODY IS DIFFERENT, SO WHAT MAY WORK FOR YOU MAY NOT WORK FOR ME. I've been on PRISTIQ for a month and it is working! The side effects that I have had so far are from stopping the ATIVAN after taking it for almost 2 years. So I think this new product may help many people out there. When taking it just make sure you don't mistakely accuse Pristiq of side effects when could be discontinuation effects from the prior medicine! Keep an eye on that!.
Good luck everyone
I've tried taking Pristiq 2 different times and both time broke out in a rash around my neck. The first time I was told it was not the Pristiq but when it happened a second time how could it be anything else? Is this the same chemical compound as Effexor? I need an antidepressant but not tolerating any I've tried. Paxil causes too much weight-gain.
I'm a 24yr old female who took effexor for 4 years at 150mg, also with the occasional use of ativan, with many side effects. Apparently I'm medication sensitive. I tried earlier this year to change medications. I started with welbutirn 150mg. Felt so sick every day. Went form that to cipralex 10mg a day, then to remron at 15mg, then to welbutrin at 300mg and now pristiq. You can pretty much say Ive been thought the ringer! But still with no sign that I'm getting better I'm completely lost. My anxiety disorder is taking over my life, and with all the doctors Ive seen there really isnt one who's helped me....
I have to agree with the answer going off effexor to this - i went from 150 mg of effexor xr to pristiq 50 mg and have had a nagging low level depression with bouts of more depression and crying and inability to handle my emotions that i hadn't had in forever with effexor. effexor was the first thing that ever worked for me. so i'm switching back to save myself from this inability to function. i was actually on the web tonight doing searches to see if anyone else reported what i was experiencing - i'm glad to see i'm not alone (but sorry for your struggles). back to effexor when it arrives weds.
I am in the process of switching from effexor to pristiq--I was on prozac for many many years it worked. Nothing else has. Menopause on top of all this for a 38 year old female stinks. I was up to 225 mg of effexor to 150, then to swap to 50 mg of pristiq--feel like I'm going thru withdrawals. Guess we will see what happens in a few days. I cry all the time and couldn't find my keys yesterday and I put them on top of the fridge ....didn't even remember picking them up...
ive been on Pristiq 50mg for 3 weeks for GAD and depression, and ive never felt so good in my entire life. Ive also never been on anti depressants before either. I was skeptical about all antidepressants, but i finally came around, and i cannot believe ive struggled for 30 years without meds. i cannot compare with any other antidepressants, but i can say that im very happy with Pristiq. this is not a corporate instigated endoresment! hope everyone finds what works for them and good luck:)
i'm going to Lucy. I'm currently taking 150 effexor and have just been given 50mg of pristq.......i have side effects form effexor like no libido, dry mouth,i'm still depressed,either really up or really down so it can't hurt to try pristiq. I n my opinion, if you are unhappy with effexor,why not try something else? hope this helps sweetie......you're not alone:}
Hi guys and gals, I am 28 years old suffered from depression since i was 17. Over the last 3 years I am suffering from PTSD and servere depression Disorder I have been tryin to find the solution for my issues.
I began on lexapro, Elavil, and then Effexor 75mg and I felt "cured", i felt the best in 10 years, though 12 months later, dose had to be uped to 112.5 then 150mg and the ova last months 225mg.
In the last 12 months i had felt no possitive effect from the dose increases just increased side effects headpressure, shakes, lowered appitie, lowered sex drive, you all know the rest we are all on a similar jurney's.
I attepted to swithch to cybalta 6 months back. My body and brain reacted in a way as if they could not commusicate together proberly
Here are just a few side effects i encounted over the 9 days of transistion, visually and sonic holutions(wiithin dreams aswell as fully consious), sensitivity the light, convoltion, uncontrolable fear and paranoia sweat hot and cold, when i could stand my equalibriam was gone. So my only solution was to go immediatly back on the Efexor and with 5-10 days the sympems had reduced to a point in which I felt in control again.
All this said today I am attempting another transition from 225mg effexor to the base dose 50mg of Pristiq.
As these are both SNRIs and metabilise through threw liver in a very simlar way, So Because of this reason and throughor research I have created a plan to ellimate most if not all negative side effects suffered during this transition.
Day 1 Take my normal 225mg Effexor
Day 2 Reduce dose 150mg Effexor + 50mg Pristiq
Day 3 Reduce dose 112.5mg Effexor + 50mg Pristiq
Day 4 Reduce dose 75mg Effexor + 50mg Prisiq
Day 5 Reduce dose 37.5 Effexor + 50mg Pristiq
Day 6 Now I take my 50mg dose of Pristq everyday
NOTE: IF THE SIDE EFECTS FROM THE EFFEXOR ARE STILL THERE AFTER 6 DAYS I TAKE A 37.5MG DOSE OF EFFEXOR EVERY 2 DAY WITH MY 50MG PRISTIQ.
WITHIN ANOTHER 7 DAYS THINGS SHOULD BE CLEAR AND THE PRISTIQ WILL BE WORKING AT IS MAXIMUM.
**********************************IMPORTANT TO ALL READER************************************
I AM NOT A TRAINED DOCTOR OR A PHARMISTIST. THIS IS JUST MY STORY, MY IDEAS AND THOERIES WHICH HAVE COME FROM YEARS OF RESEARCH, LIVING AND RELYING ON THESE MEDICATION EVERYDAY.
PLEASE DONT TRY ANYONE ELSES METHODS WITHOUT DOING YOUR OWN EXTENSIVE RESEARCH.
I EMPLOY YOU IF YOU ARE SERIOUS ABOUT FINDING THE BEST MEDICATION FORSELF WITH HELP FROM YOUR GP LEARN AND UNDERSTAND HOW THE MEDICATION ACTUALLY WORKS AND EFECTS YOUR BODIES, IN'S AND OUT'S
MANY OF US MAY NEED ANTIDEPRESANTS FOR OUR ENTIRE LIVES. LIFETIME USE IS NOT WHAT ANTI-DEPRESANTS WHERE DESIGNED FOR AND WE DONT KNOW WHAT EFFECT THE LONG TERM USE OF THESE MEDS ARE GOING TO DO TO US IN YEARS TO COME.
Try to see this "pill" we take in the morning/night as a health suppliment and incormerate it into a heathy eating and exercise pattern over 3/6/9 months and see what happens. What is 3/6/9 months out of you life if it changes it for the good from then on.
Love you all my fellow medicated men and women.
P.S. "if any ones tells me ta keep me chin up" I'm gonna knock theres right off theres face:P
Everyone here should be aware that drugs like Effexor and Pristiq work differently for different people. What doesn't work for one may the best option for another. The important thing is to be closely monitored by a Psychiatrist, not a GP or NP, mental illness is their expertise. This is hardly a battle over my anti-depressant is better that yours. If you are looking for feedback from other people chatrooms and blogs are fine, but remember to keep your mind open because your personal expereince may differ drastically.
im currently on effexor 75mg and don't have a gp or seening anyone on a regular basis to get my med. i went close to a month without it.after the crippling physical side affects passed, i thought i was out of the woods, then the "brain glitches" started,i could not go five min. without the feeling that my brain was short circuiting. i got back on the 75mg by going to the emergency room and ran out for two days and i thought that i would rather be dead than to feel like this because i have missed a couple of doses!. i literally could not function and thought "oh my god this is what like a heroin addict must feel like"!! i am down to 37.5mg and im slowly being weaned off,the thought of needing something so badly just frightens me. im afraid to try pristiq because besides the d-e-s-, all i see is venlafaxine which is generic effexor!for anybody that has had success with either drug,god bless you and thats so great! for me though this has been a nightmare and i finally have some hope that i can eventually wake up from.
i was on effexor 75mg and don't have a gp or seening anyone on a regular basis to get my med. i went close to a month without it.after the crippling physical side affects passed, i thought i was out of the woods, then the "brain glitches" started,i could not go five min. without the feeling that my brain was short circuiting. i got back on the 75mg by going to the emergency room and ran out for two days and i thought that i would rather be dead than to feel like this because i have missed a couple of doses!. i literally could not function and thought "oh my god this is what like a heroin addict must feel like"!! i am down to 37.5mg and im slowly being weaned off,the thought of needing something so badly just frightens me. im afraid to try pristiq because besides the d-e-s-, all i see is venlafaxine which is generic effexor!for anybody that has had success with either drug,god bless you and thats so great! for me though this has been a nightmare and i finally have some hope that i can eventually wake up from.
I switched from Effexor to Pristiq about 3 months or so ago. I thought it might be good to try the latest verison, so to speak, and thought that perhaps it would help with my weight (I have always seemed to be holding on to about 20 pounds more then usual) and my sex drive (not amazing). I also loved the idea of not going through huge withdrawl (brain shakes and feeling like you're being dragged around your bed while sleeping, anyone?) if I forgot to take a dose. When I heard about Pristiq, I thought to myself, "finally- they fixed that; sign me up!"...
After a month on Pristiq and more bouts of depression and uncertainty then I had experienced for a quite some time (as well as what I can only call a nervous breakdown day), I was moved up to the double-dose.
Within a few days things seemed to even out a bit. But after a few weeks now, I feel off again.
I still cry alot now. I worry so much more. My anxiety is through the roof. And then suddenly for an hour, I feel ok. And then, it goes away and I'm down again. I once missed a turn-off on a familiar drive and drove for another hour and a half before I realized my mistake. It was like I forgot what I was doing but kept going anyway. I find at times when in conversation that I keep babbling, and say things a bit more hap-hazardly then I mean to. I can hear myself talking, and at times, due to not being clearminded, neither is how I explain a concept or an idea. It's like I am missing the beat that I used to be able to keep to.
Yes, I have a stressful life as a small business owner, however I've noticed lately while journaling that I am panicing over things that I used to be able to handle. I've lost some wieght, which is nice, but I was always naturally skinny (too skinny) before I went on meds a decade or so ago. All my nervous stress seemed to keep fat at bay. Well, I now feel alot like I did back then. Constantly nervous. Worried. Not overly hungry as I've been worrying.
I'm a Christian, so my mindset is that I'm not in this alone. I beleive God gives us disernment to clue in when things aren't well. Well, for me, things aren't great on Pristiq, and I'm going to set up an appointment with my Doctor to go back on Effexor if he agrees that my case warrents it.
If Effexor means weight gain, then I will have to be more active to counter it. If it means a lower sex drive, then when I'm married one day I'll have to deal with it (hellllo, blue pills!). But right now, I'm just not myself, and it is literally scaring me.
I thought going on Pristiq would finally give me the benifit of my meds without the side effects I had encountered before. For me, it doesn't seem to be a good match. I'm really disappointed about that, but I need to stay on track and healthy.
I will post again and update the situation.
For me the pristiq gets rid of the mood swings I had with the effexor both times I was on the effexor, I'd either be a zombie from too much and even out towards the end of the day or when I needed a high dose of effexor I'd have it run out of my system before the next dose and the pristiq gives me a more even feel, like either I'm a zombie on too much so they know to wean the dose down or feel how I should which is not depressed or if I feel a little worse, increase the dose. I think it depends on your metabolism.
Get the right mix! My psych. always waited about 3-4 weeks before us evaluating. It takes that long to know! We went through about 7-8 different mixes before hitting the one that worked. And this guy is a wizard. Trial and error stinks, but it seems to be the answer for now. For me, it was worth it. Part of my mix is Pristiq. Just wish it weren't so expensive.
I did not have time to read through what everyone above has written but i wanted to add that about 3 years back I was switched from Effexor to Lexapro and I went through complete hell trying to get off Effexor (anxiety attacks). i was later switched to Pristiq and it has been the most affective anti depressant I have ever taken and I've had them all at some point. I guess this is the opposite of what most others seem to be saying but thats my experience :) Thanks, Ky
I took Pristiq for 2 years, and it was a miracle drug for me. However, I unfortunately had immediate sexual side effects (anorgasmia) even on the lowest dose. I have been off of all meds for a year now, and the sexual side effects have disappeared. Unfortunately, the depression is back. I started taking Pristiq again and almost immediately felt better... but the sexual side effects returned immediately, as well. Go figure. After a year without the problems, it's really hard for me to go back- despite the fact that I'm mentally so much better. I am hoping I can find something that gives me the best of both worlds... kind of like a naturally healthy brain. Wouldn't that be nice?!
I understand that pharmaceutical companies are pretty much evil, etc., but it really is true that all of these drugs affect people in vastly different ways. I guess I am relatively lucky that I haven't experience the horror stories that have been listed here. And I am at least thankful I have so many more options than my father or his father or his father's father did...
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