Hi Penny   Are you talking about Effexor?    Health Central has some information you can read about this particular drug here.   Know that I am not a doctor nor have I ever used this medication.  But in researching your question I found a message board where people discuss the weight gain issue and taking effexor.  It seems a mixed bag.  Some people gain weight and some don't.  You can find that discussion here.    I think everyone's metabolism is different and so everyone will respond differently to the meds.  I think the best thing I can tell you is to talk about all this with your doctors.  They are going to know the most about the side effects and be able to treat you accordingly.   I hope you find the med which helps you the most and has the least side effects.   Thank you for your question!