I'm currently on 300 mg of Effexor and feel great except in the 10 days before my period. To complicate matters, I'm also deep in perimenopause (I'm 52). I'm going to talk to my psychiatrist, but anyone else out there had similar problems? Could it be the Effexor is not working as well as it had (only been on it since early 2006) or could the perimenopause really be screwing things up? I should add that we increased the Effexor dose from 262.5 mg to 300 mg in September as SAD and work-related stress were really affecting my depression.






Hi, Merely Me - Thanks for your response. Part of the reason my psych doc raised my Effexor is because of the SAD, which for me tends to start in August - when I see the days getting shorter, it just gets to me, but this year has been the first year in a long time I've had such an intense response. To make matters worse for me, I also have a 4-cm uterine fibroid, which we are treating medically with Prometrium, which does help with the mood swings a bit in that I'm not so estrogen-dominant. Oh, and did I mention I'm also a migraineur? My migraines have increased from an average of 1 a month to 2 to 3 a month; Thursday and Friday, I had 2 different migraines in 2 days! I was lucky to be able to abort the 2nd one thanks to getting a visual aura. It's all so complex! Yes, perimenopause can indeed last 10 years - my first night sweats started at 37(!) but I've really noticed it the last 4-ish years with the other "symptoms." I keep a combination mood/migraine/menstrual diary in my appointment book - it can be very helpful to see what's going on for all my docs (internal med, psychiatrist, GYN), but it can be hard to separate which is migraine-related, which is cycle-related . Cycle-wise, yesterday was 19. I've been taking fish oil. I'm lucky enough to have a window by my cubicle at work and to drive to work in daylight year-round, which helps. I've tried soy (no help), black cohosh (no help). Any other tips, including more on SAD, would be appreciated!