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Wednesday, April 08, 2009 NanaNutt, Community Member, asks

Q: Is it possible to build up an immunity to fluoxetine?

I have been taking this drug for about 15 years and this past year I still feel the old depression seeping in. The Dr. upped my dosage but I feel no different. Is this because I am just getting old?

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Answers (1)
Teri Robert, Health Guide
4/ 8/09 5:33pm



Absolutely. In the case of medications, it's called building a tolerance.


Prozac is infamous for this, so infamous that a tolerance to medications has been nicknamed "the Prozac poop-outs."


Please discuss this with your doctor. It may well be time for a different medication.


Good luck,


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By NanaNutt, Community Member— Last Modified: 12/01/10, First Published: 04/08/09