I am a 59 yo women and have been taking both of those meds: Wellbutrin and Prozac, among other medications, for many years without any side effects beyond the usual side effects of psychiatric meds.   Every persons metabolism is different though. So what is OK for me may not be for you. My philosophy on meds is that I give it a try and be vigilant about any changes I feel after a week or 2 on the meds. Sometimes you will get side effects that occur just for the first few days opr weeks as your body is adjusting to the meds. Buts these effects usually fade out after a week or two. I hope this helps!?