Thanks so much for the response I think it's so caring to use your valuable time for others

 I am giving most of my whole story in case someone else might find similarity in their own issues.

My Mother had depression (Lithium and mental hospitals in the old days) and I guess It's in my genes. I was never quite (with-it) as I call it (normal for the psycholgists) for most of my life. always teased etc. At 45 I finally went for help. I've takin All the different meds for Depression, and they all worked for a while then they would became ineffective.  Prozac was the first at age 45 and life was fantastic. I felt the effects of the Prozac 2 hrs after I first took it! For 2 years, I was witty, and creative and talanted in every area (not manic).  It's effect finally wore off and so I tried all the others until only effexor was the main Med that would worked on and off for about 5 yrs. It Caused me to have high blood presure and since I had low platlets I stopped until the platlets came were cured. The last 3 years where effexor and now changed to Pretiq (it's good for Blood Presure) and recently I read about  (retellin) I think it's called, used for attention defficite kids, I tried that just to see if maybe I had always had ADA. Nothing changed, Then I read about Deplin with effexor. My Doc gave me all three for a trial. It's been about 2 months and this combo made me so sleepy that I could never get enough sleep. I havn't had 5 great days in 5 years. I ran out of my effexor accidently so I just tried the Deplin with the ADA med and Bam! I was back to my old game. So far I've had 5 great days, but not manic. I have been disapointed for the last 20yrs since all my meds seem to lose effectivness after a time. I hope I'm on to something by luck. Maybe I am a rare case of having really a low folate disorder. The ADA gives me some energy, with the mental clearity, I tried the ADA by itself too and only felt slightly naseuated, no improvment.

 On a tangent, If someone know how I could be a research subject so they could scan my brain activity to see what changes in the brain changed with different Meds. When a Med works for me I can tell the difference in 1 Day, I'm sensitive to my mental mood and whether I am depressed because I play guitar and can be very creative with humor when I am (with-it). I miss the good old days of not being depressed, maybe I pray this one will last, On the other hand what choice do I have! I'm 58 with 4 kids (twin 7yr. olds) 12, and 15 yr. old. I need a good day just to keep up.

 If you are treating yourself with the natural folate and B -12 I belive this Deplin is natural but as in the original post kicks butt when it comes to converting of helping the seritonin type chemicals do their stuff, . It is inexpensive too.

PS Please excuse the grammar and no spell check that I could find.

<!--Session data-->

<!--Session data-->

<!--Session data-->

<!--Session data-->