TEB I dealt with the same situation. When my wife chose not to use the medication and after trying every other way. I ended up using Tough love. I packed her stuff and put them by the door and called a Taxi. I told her that I love her but I also was responsible for my children and could not continue dealing with her depresion if she was not willing to help. She had a choice the medication or get out. She has taken the medication ever since. But you have to be resolute to let her go otherwise she will manipulate you with guilt trips and accusation. Remembber you are doing it both for her own good and to keep your and your kids sanity. Best of luck