This all sounds very familiar... my wife had a severe reaction forst to prazac and then effexor.  It changed her personality and made her depression worse to the point of a suicide attempt.  She fell out of love with me, infact hated me and said she had never loved me, accused me of being abusive and controlling and even said she was scared of me hitting her!     Long story short, after a long and difficult withdrawal we got her off the drugs and she feels like she just woke up from a nightmare.  She is ridden with guilt over the false accusations and true personality has returned. Now we are happy again.   The drugs turned her into a monster.