may be described as feeling sad, blue, unhappy, miserable, or down in the dumps. Most of us feel this way at one time or another for short periods.
True clinical depression is a mood disorder in which feelings of sadness, loss, anger, or frustration interfere with everyday life for weeks or longer.
Depression - major; Unipolar depression; Major depressive disorder
Causes, incidence, and risk factors
The exact cause of depression is not known. Many researchers believe it is caused by chemical changes in the brain. This may be due to a problem with your genes, or triggered by certain stressful events. More likely, it's a combination of both.
Some types of depression run in families. But depression can also occur if you have no family history of the illness. Anyone can develop depression, even kids.
The following may play a role in depression:
Alcohol or drug abuse
Certain medical conditi...
What is the difference between dysthymia and major depression? The simple answer is severity, but let me expand on this further. Technically, dysthymia is a pervasive "low level" depression that lasts a long time – often a few years. "Major Depression" is a discrete episode of severe depression. When it is gone, the patient is in "remission,” and feels completely normal. "Recurrent major depression" comprises discrete periods of major depression that come and go, while "major depression in partial remission" is a severe discrete episode that never completely gets better. How does that feel any differently than dysthymia, you might ask? It doesn't. These terms are descriptions, not different diseases. The problem with these terms is that the medications are pretty much the same: antidepressants. Ostensibly, the diagnosis is supposed to have predictive value. For example, there are high rates of relapse in partially treated depression, while dysthymi...
The FDA has approved EMSAM (selegiline), a transdermal patch,
for the treatment of major depression. Selegeline is a MAOI
originally used to treat Parkinsons. MAOIs belong to an old
class of antidepressants, typically used as a last resort. When
taken orally, side effects with these meds tend to be onerous,
including risk of tyramine reaction and resulting hypertensive
crisis, which necessitates severely restricting ones
The patch was developed by Somerset Pharmaceuticals, who
partnered with Bristol-Myers Squibb. Because the drug is absorbed
through the skin, there is little or no contact with gastric
tyramine and interactions with various enzymes. Based on three
small studies, the product labeling advises that a modified diet is
not required for 6 mg a day of EMSAM. But due to limited data, the
labeling advises that those on doses of 9 and 12 mg are required to
restrict their diets. If hypertensive crisis occurs, the drug
should be discontinued immediately and thera...
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