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Hi!  Hang in there; it gets much better.  I never got on the   cymbalta; it has more side-effects compared to Wellbutrin; which Dr added at a low dose of 150 mg 1x daily.  I have been waking fine all last week and this week also.It takes time for this to work but your Dr may add another like wellbutrin or something for a boost to pristiq.  Keep in touch and I will eep you posted; not to give up yet; I had some tiredness too; it gets better when your body gets adjusted and you take it in the morning usually. I also take a good brand of omega 3 capsules from a health food store which is known to help with depression also and other good things about it.  Thank you and good luck --Sandy
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