I have been on Effexor ER 37.5 mg for several years (sometimes taking it just every other day) and due to an unrelated kidney stone incident, it was discovered that my enzymes were high. I was advised by my doctor to stop all Advil, Motrin, etc., which I was taking fairly regularly, and get re-tested in 30 days. I did that and they are still elevated so now I have to have an ultrasound of my liver. I feel healthier than I have in years due to the fact that I can exercise regularly (I had a bad bout of plantar fasciatis) that has reasolved so I'm hoping that it's the Effexor ER. I am going off of it for good this time as I don't like taking it with the unknowns about the liver, etc. I experience withdrawl symptoms that are quite bothersome (sensitivity to light, brain "zaps", etc.) but I'm determined to get off it for good this time. Good luck with your results.