Always take antidepressants in the AM, except for sedating ones such as Remeron. Give it a try. And if you don't have a psychiatrist prescribing your meds, get one. They know the meds very well and will work with you to find a schedule that is best. Even if you have to pay out of pocket to see him/her every two months or so, it is worth every cent. Feeling better is priceless. Good luck.