From what I've read, in the drug trials of many of the SSRI and SNRI antidepressants, weight loss is usually what was observed. These trials are usually not long-term studies, however.   Some seem to gain weight on various SSRIs, some lose weight. Celexa and Effexor, in the trials, were favorable towards weight loss.   But, as Dr. Walcutt mentioned, if it cheers you up enough to suddenly give you an appetite that you didn't have before, in your case, it could mean weight gain.   Your mileage may vary. Eat healthy foods and you're less likely to gain weight. Avoid junk foods, high-starch foods, and high sugar intake, and you will probably not notice any weight gain. You don't need to diet, you just need to be reasonable. If you avoid foods with lots of preservatives, artificial colors and flavorings, you may find that you feel better staying away from those additives. It certainly can't hurt to try.   Donald