It has long been thought that Cymbalta (generic name duloxetine) would be the second medication to receive FDA approval for the treatment of fibromyalgia . However, the disappointing results of the third phase III efficacy study could stall Lilly’s quest for approval. The 27-week phase III clinical trial randomized 330 fibromyalgia patients to either a 60 mg or 120 mg per day dose or to a placebo. Patients were allowed to switch between the 60 and 120 mg dosages during the study according to efficacy and tolerability. Study Results Cymbalta failed to achieve a statistically significant difference over the placebo in the primary outcome measures. The mean reduction in pain severity (measured by the Brief Pain Inventory) was 1.62 for Cymbalta and 1.12 for the placebo. The patients’ impressions of improvement scores averaged 3.42 for Cymbalta and 3.73 for the placebo. Cymbalta also showed no significant improvement in physical function. This study stands in stark contr...
The goals of treatment are to reduce the immediate withdrawal symptoms, prevent complications, and begin long-term therapy to promote abstinence (no drinking at all).
People with moderate-to-severe symptoms of alcohol withdrawal may need inpatient treatment at a hospital or other facility that treats alcohol withdrawal. Others who may need inpatient treatment include those who:
Have a mental health disorder, such as schizophrenia or bipolar disorder
Have failed outpatient treatment for alcoholism or alcohol withdrawal
Have serious medical problems
May be harmful to themselves or others
Treatment at an inpatient center will include medical monitoring and treatment of alcohol symptoms.
Monitoring of blood pressure, body temperature, heart rate, and blood levels of different chemicals in the body will take place. The person will be watched closely for hallucinations and other signs of delirium tremens .
Symptoms Primary symptoms may include: Agitation and restless behavior Depressed mood Fatigue Generalized malaise Increased appetite Vivid and unpleasant dreams Slowing of activity The craving and depression can last for months following cessation of long-term heavy use (particularly daily). Withdrawal symptoms may also be associated with suicidal thoughts in some people. During withdrawal, there can be powerful, intense cravings for cocaine. However, the "high" associated with ongoing use becomes less and less pleasant, and can produce fear and extreme suspicion rather than joy (euphoria). Just the same, the cravings may remain powerful. Signs and tests A physical examination and history of cocaine use are sufficient to diagnose this condition. A toxicology (poison) screen may be performed to see if other drugs may have been taken.
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