Hello Cher
When you say they didn't work for you...can you elaborate about how they didn't work. Did you experience too many side effects? Do you still suffer from depression while on them? Did you feel any better at all on any of them? Which was the best one of them all for you? And did you take them for the recommended time?
There truly are so many different antidepressants out there and some people take a combination of them.
Other tools to help with depression of course include therapy, diet, exercise, and so forth.
I myself....have gone the natural route and am taking sam-e which has been effective for me but may not be for someone who is treatment resistant.
I have heard of deep brain stimulation for folks who have exhausted other methods. I don't know much about it though.
What is your goal with your mood? What would you like to feel or not feel? What are your expectations of depression treatments. It is my opinion that there is no pill out there which is going to make us happy all the time. Meds might take the edge off or help us to cope better but...the happy part takes a bit more work.
Wish I could be of more help. Thank you for asking this question.
Make a list of your depression symptoms. The reuptake inhibitor types, like Effexor, Zoloft, Prosac, don't affect dopamine much,, although they do get you out of the black hole. Wellbutrin and a few others do affect dopamine - and that's for motivation, energy, and positive outlook. That was the trick for me - after 13 years of also trying a lot of them. I needed the dopamine effect.
A lot of people are afraid to lose control to a drug, so they give up after a few days and say "it's not working." Some meds work quickly (I could feel the Wellbutrin cheering me up after just a few days). Some meds take several weeks.
Be patient! Research on the internet, and do the other stuff that's suggested - exercise (I walk around the parking lot at work before I go home). Eat better, too, less junk, more whole grains, fruit - you know.
I've been in AA for 25 years - lots of helpful stuff in 12-step programs of all kinds. One of my favorite sayings is "We need something to do, someone or something (pets) to love, and something to look forward to." So make sure you have some work you feel good about, and a person or pet you love, and plan a trip, or even just a night at the movies - it helps make the world seem brighter.
Don't give up! It took me 13 years to find the right meds, but I know there is always a solution! Oh, and don't let your ego take over - be grateful, and hopeful, and keep in touch!
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