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Monday, November 22, 2010 Jean asks

Q: Can increased seratonin cause the limbic system to go into overdrive and prevent the pre-frontal cortex from being accessed. For example, in the case of severe anxiety.

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John Folk-Williams, Health Guide
11/23/10 4:02pm

I'm not a medical professional or neuroscientist but a layman who's recovered from depression and has had experience with a lot of antidepressants that increase the level of serotonin. That said, there are all sorts of issues tied into what you ask. In mentioning those brain areas, I assume you're talking about extreme emotion overwhelming rational thinking. Most of what I read about the brain these days is full of caution about tying one function exclusively to one system or part of the brain - so it would be clearer if you described the actual experience and concerns - or whether you're worried about what may happen if you start taking a drug that increases serotonin.

 

(I'll assume you're talking about increased serotonin due to antidepressants that target that neurotransmitter. There are many other drugs that have this effect but are not aimed at depression - they alter other chemicals in the brain as well.)

 

There is a long list of potential side effects for the antidepressants. Many of those tend to dull feeling rather than arouse it, but anxiety is also a possible side effect. The specific effects vary with each person. That's why a psychiatrist starts a new drug at a low dose and gradually builds up - to see exactly how you're reacting to it.

 

I'm certainly not qualified to answer your question, but these are some or the issues that occur to me. Hope that helps.

 

John

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By Jean— Last Modified: 12/27/10, First Published: 11/22/10