I've be on pristiq for 2 months and not real happy with it yet.  I had to fight so hard to get my insurance to cover it that now I feel stuck with it.  My PA would crack if I told her I wanted something else.  I think I need to got to my Psychiatrist which is 60 miles away and tell him them symptoms though.  Last night granted I was exhausted, I felt like I was going to go crazy.  Thankfully my husband was home to help with the child.  I even swore at her.  She is only 3.  I have always had Major Depression but on this med I almost feel Bipolar.  One day great next day I'm evil.  I've always been a really passive person but on this med I'll tell people off without even thinking about it.  Not like me at all.  I may have to go back to my good old Celexa.  I tried it because it has norepher... and serotonin.  Which Celexa just has serotonin.  The only good thing is I do have a sexual desire which on celexa I could care less if I ever did that again.  Well see I may try hold out one more month.  I just hate being mean though.