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No. Migraine is a genetic neurological disease caused by genetics and overactive neurons in the brain.   That said, there's a huge difference between the cause of the disease and triggering individual Migraine attacks. Depression cannot trigger Migraines. There's still some controversy over whether or not stress is a trigger. The most prevalent thought on this is that stress itself is NOT a trigger, but it does make Migraineurs more susceptible to their other triggers. For more information on this, see Is Stress A Migraine Trigger?   Hope this helps! Teri