Hi JMG: Actually, there is information about Wellbutrin causing skin problems as a side effect. Allergic-type reactions are not unheard of.  Rashes, pruritus, urticaria (hives), angioedema, dyspnea, erythema multiforme (Stevens-Johnson Syndrome), and anaphylactic shock has been associated with bupropion. But, there may be other factors here that you haven't considered. Before you do anything, please consult with your doctor (and your dermatologist) if you develop any symptoms that seem unusual.   Best of Luck, Dr. Diana Walcutt   *Dr. Walcutt is a Psychologist. Dr. Walcutt's answers are not intended to diagnose or treat any medical or mental disorder. Any information given in a post about medication is for educational purposes only, and primarily to aid you in having an informed discussion with your own Psychiatrist/Physician.