It's definitely an inexact science. What a disappointment it must be to take medications that don't improve your situation. I'm nearly as old as you and have been struggling with the same issues for many years. I am fortunate that I have found some medications that seem to help - at least temporarily - but some of the problems never go away completely. I have a great doctor, but I still don't have an exact diagnosis. I'm either depressed about being anxious or anxious about being depressed. This may sound silly, but I just spent a week traveling - a major stressor for me - and found some relief by repeating the word "impermanence" silently to myself. It was something I read on another post. Just a reminder that the suffering does not last forever, even though it feels like it will. It helped a little. Sorry, I'm rambling. I sympathize with your dilemna. Best to you.