Zoloft Oral

Zoloft Oral Interactions

See also Precautions.

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop or change the dosage of any medicine before checking with them first.

Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) within 2 weeks before, during, and after treatment with this medication. In some cases a serious, possibly fatal drug interaction may occur.

This drug should also not be used with the following medications because very serious interactions may occur:

• pimozide
• sibutramine

If you are currently using any of these medications, tell your doctor or pharmacist before starting sertraline.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

• drugs for diabetes (e.g., insulin, tolbutamide)
• other antidepressants (e.g., SSRIs such as citalopram/fluvoxamine, TCAs such as amitriptyline/desipramine, other types such as venlafaxine/nefazodone/trazodone)
• drugs which can cause bleeding/bruising (e.g., anticoagulants such as heparin and warfarin, anti-platelet drugs including aspirin/NSAIDs such as ibuprofen)
• buspirone
• dextromethorphan
• certain herbal/supplement products (e.g., melatonin, St John's wort, tryptophan)
• lithium
• drugs for migraine (e.g., dihydroergotamine, "triptans" such as sumatriptan)
• stimulants such as amphetamines/phentermine
• street drugs such as MDMA ("ecstasy")

Sertraline can affect the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include cimetidine, cisapride, clozapine, and certain drugs for heart rhythm such as flecainide/propafenone, among others. Consult your doctor or pharmacist for more details.

Also report the use of drugs which might increase seizure risk (decrease seizure threshold) when combined with this medication such as bupropion, isoniazid (INH), theophylline, or tramadol, among others. Consult your doctor or pharmacist for details.