Difference Between Tricyclic Antidepressants And Ssris

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Are SSRIs Associated With Decreases in Bone Density?

Two recent articles from the Archives of Internal Medicine suggest that SSRIs are associated with an increased rate of bone loss.

 

In the first study, older women (average age 78) on and off SSRIs were followed for five years. The authors found both groups of women had decreases in bone density over 5 years, but that the rate was double in SSRI users: -0.49% vs. -0.8%

 

In the second article, older men (average age 73) were followed, and decreases in bone density were about 5% greater in...

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