Infrequently, varenicline may cause serious mental/mood changes, even after stopping the medication. Quitting smoking itself may also cause mental/mood changes. Stop taking varenicline and tell your doctor or pharmacist immediately if you have symptoms such as depression/suicidal thoughts, agitation, aggressiveness, or other unusual thoughts or behavior.
See also Warning section.
Nausea, headache, vomiting,...
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Source: First DataBank
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