Italian researchers have found that Lexapro and Zoloft are the best of 12 new-generation antidepressants, while reboxetine (sold as Vestra and Edronax) is the least effective. In the study, scientists tested a wide range of new antidepressants and found that Zoloft and Lexapro were the best in terms of effectiveness and patient acceptability. Two other new antidepressants--Remeron and Effexor--were as effective the two best drugs, but more patients stopped taking these than Zoloft and Lexapro.