This past week, the FDA approved the first generic version of pioglitazone (Actos) for the treatment of T2DM.
As I had anticipated, the FDA News Release mentioned the concern that the current version of pioglitazone (Actos brand) has been associated with some nasty side effects, including an increased risk of heart problems, and risk of bladder cancer: “The drug has a Boxed Warning to emphasize that pioglitazone may cause or worsen heart failure, particularly in certain patient...

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