Prozac had been around for about 6 years when I was prescribed it in 1994. From one of the deepest depressions I ever had, it raised me into mild hypomania that lasted fully for a year, then waned over the next two years. I also gained 30 pounds in the first two years I took it, going from an underweight 115 (I was 5'10" and looked good between 125 and 135 pounds) to a beginning-to-be-unattractive 147.

After that, the effect waned fast, and by 1999, just 5 years later, it wasn't working at...