Generic Name: PHENELZINE - ORAL
Pronounced: (FEN-el-zeen)

Phenelzine Oral Interactions

Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious (possibly fatal) interactions may occur:

• other antidepressants (e.g., TCAs such as amitriptyline/nortriptyline, nefazodone, SSRIs such as citalopram/fluoxetine/paroxetine, venlafaxine)
• appetite suppressants (e.g., diethylpropion, sibutramine)
• drugs for attention deficit disorder (e.g., atomoxetine, methylphenidate)
• certain antihistamines (azatadine, carbetapentane, chlorpheniramine)
• bupropion
• buspirone
• carbamazepine
• cyclobenzaprine
• dextromethorphan
• certain drugs for glaucoma (e.g., apraclonidine, brimonidine)
• certain drugs for high blood pressure (e.g., guanethidine, methyldopa)
• other MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, procarbazine, rasagiline, selegiline, tranylcypromine)
• certain narcotic medications (e.g., fentanyl, meperidine)
• certain drugs for Parkinson's (e.g., entacapone, levodopa, tolcapone)
• street drugs (e.g., MDMA/"ecstasy", LSD, mescaline)
• stimulants (e.g., amphetamines, cocaine, dopamine, epinephrine, phenylalanine)
• tetrabenazine
• "triptan" migraine drugs (e.g., sumatriptan, rizatriptan)
• tramadol
• tyrosine
• tryptophan

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting phenelzine. Do not take these medications within the 2 weeks before, during or after treatment with phenelzine. If you have been taking fluoxetine, wait at least 5 weeks after stopping fluoxetine before starting phenelzine. Discuss with your doctor how much time to wait between starting or stopping any of these drugs and taking phenelzine.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

• drugs for diabetes (e.g., glyburide, insulin)
• drugs for high blood pressure (e.g., beta blockers such as atenolol, clonidine, rauwolfia alkaloids such as reserpine, "water pills"/diuretics such as hydrochlorothiazide)

Also report the use of drugs which might increase seizure risk (decrease seizure threshold) when combined with phenelzine such as isoniazid (INH), phenothiazines (e.g., thioridazine), theophylline, or tricyclic antidepressants (e.g., imipramine) among others. Consult your doctor or pharmacist for details.

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., phenytoin), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, lithium, risperidone, trazodone).

---