IMPORTANT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate or effective for you. Consult your healthcare professional before using this drug.
Phenelzine Oral Interactions
Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop or change the dosage of any medicine before checking with them first.
This drug should not be used with the following medications because very serious (possibly fatal) interactions may occur:
- other antidepressants (e.g., TCAs such as amitriptyline/nortriptyline, nefazodone, SSRIs such as citalopram/fluoxetine/paroxetine, venlafaxine)
- appetite suppressants (e.g., diethylpropion, sibutramine)
- drugs for attention deficit disorder (e.g., atomoxetine, methylphenidate)
- certain antihistamines (azatadine, carbetapentane, chlorpheniramine)
- certain drugs for glaucoma (e.g., apraclonidine, brimonidine)
- certain drugs for high blood pressure (e.g., guanethidine, methyldopa)
- other MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, procarbazine, rasagiline, selegiline, tranylcypromine)
- certain narcotic medications (e.g., fentanyl, meperidine)
- certain drugs for Parkinson's (e.g., entacapone, levodopa, tolcapone)
- street drugs (e.g., MDMA/"ecstasy", LSD, mescaline)
- stimulants (e.g., amphetamines, cocaine, dopamine, epinephrine, phenylalanine)
- "triptan" migraine drugs (e.g., sumatriptan, rizatriptan)
If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting phenelzine. Do not take these medications within the 2 weeks before, during or after treatment with phenelzine. If you have been taking fluoxetine, wait at least 5 weeks after stopping fluoxetine before starting phenelzine. Discuss with your doctor how much time to wait between starting or stopping any of these drugs and taking phenelzine.
Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:
- drugs for diabetes (e.g., glyburide, insulin)
- drugs for high blood pressure (e.g., beta blockers such as atenolol, clonidine, rauwolfia alkaloids such as reserpine, "water pills"/diuretics such as hydrochlorothiazide)
Also report the use of drugs which might increase seizure risk (decrease seizure threshold) when combined with phenelzine such as isoniazid (INH), phenothiazines (e.g., thioridazine), theophylline, or tricyclic antidepressants (e.g., imipramine) among others. Consult your doctor or pharmacist for details.
Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., phenytoin), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, lithium, risperidone, trazodone).
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
Information last revised September 2011 Copyright(c) 2011 First DataBank, Inc.