Saturday, June 02, 2012

Nutritional/Vitamin Supplements for Diabetes

By Andrew Berry Thursday, August 06, 2009

 

(Click this link to see Andrew's articles and interviews with Andrew on exercise, nutrition & diabetes.)

 

While diabetes most noticeable impacts the way your body processes glucose and your blood sugar levels, other parts of the body are effected over time. Of course, well managed blood sugars will reduce the impact on your body's kidneys, eyes, ability to metabolize and digest your food properly, but there are some steps you can take to help your body prevent the development of complications and aid your body in maintaining health.

 

Below are a list of the top nutritional supplements you and your diabetes can benefit from:

 

Vitamin C- In the body, there’s an enzyme called aldose reductase which principal job is to convert glucose into a related sugar called sorbitol (yes, the same sorbitol that is an additive in some foods that can cause gastrointestinal problems-more on this in another article). This enzyme is more active in people with type-1 diabetes. The problem with sorbitol is that it attracts water which causes cells to swell resulting in nerve, kidney, eye and blood vessel damage. This is the leading cause of diabetic cataracts. Type-1 diabetics typically have lower levels of Vitamin C because the transport of vitamin C is facililitated by insulin. Due to the impaired transport or dietary inadequacy, a deficiency may arise. So, supplementing with additional Vitamin C would be a good idea. Shoot for 1-3 grams daily through foods and supplements. (Meyer & Sekundo, 2005)

 

Acetyl-L-Carnitine- Diabetic polyneuropathy is a painful complication of diabetes that results from damage to the nerves by high levels of blood glucose. The condition can lead to cardiac arrhythmias, foot ulcers and even amputations. Acetyl-L-Carnitine (ALCAR) is the acetylated form of the amino acid l-carnitine, which helps the body transport fatty acids to be burned as energy. ALCAR has been shown to increase the number of nerve fibers and regenerating fiber clusters in type-1 diabetics. This supplement exhibits its best effect on those with early signs of neuropathy and as an added benefit, increases the use of fat as a fuel source. Aim for 500 milligrams three times daily. (Jacobs, Evans, & Evans, November 1, 2008)

 

Evening Primrose Oil- EPO is a nutritional oil that comes from the seeds of the evening primrose plant. EPO contains an important fatty acid called GLA (gamma linolenic acid) which the body converts to a hormone like substance called prostaglandin E1 which has been shown to prevent and reverse the damage to the nerves caused by diabetes. The recommended dosage is one gram three times daily. (Yasuda, et al., July 1989)

 

Biotin- is a B vitamin that is used to process glucose. In the liver, biotin aids insulin in increasing the activity of the enzyme (glucokinase) responsible for glucose utilization. Supplementing with biotin when you take your insulin may drastically increase the activity of the glucokinase enzyme, causing an improvement in your blood sugar. In one study, Type 1 diabetics were given 16 mg of biotin a day for one week and their fasting glucose levels dropped by 50%. Try taking 16 mg a day in 3-4 even doses to see if your fasting blood glucose improves.  (Holiistic Online, 1998)

 

Magnesium- is an important mineral that all diabetics are at risk for developing a deficiency.  Type 1 diabetics are more than two times as likely to develop diabetic related eye problems when they are deficient in magnesium. Lack of magnesium may also be a leading cause in the high rates of birth defects associatied with diabetes. Try supplementing with 300-400 mg of magnesium and talk to your doctor about your magnesium levels.  (Seyoum B, 2008)

 

Alpha-Lipoic Acid- ALA is a powerful antioxidant that is used to treat and improve diabetic neuropathies and reduce the pain assicaited with the condition. In one study, where diabetic patients were put on 300-600 mg of ALA for 3 months, only one out of the 100 patients included in the study, didn’t show any signs in improvement in managing diabetic neuropathy. (Bureković A, 2008)

 

Carnitine- is is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine. It is needed for the body to properly transport and use fat as an energy source. When type 1 diabetics were given carnitine at a dose of 1 mg per 2.2 pounds of bodyweight, high levels of cholesterol and triglycerides dropped 25-39% in just 10 days. Carnitine could possibly play a role in preventing diabetic ketoacidosis. (Salvatore)

 

 

 

 

References

Bureković A, T. M. (2008). The role of alpha-lipoic acid in diabetic polyneuropathy treatment. Bosnian Journal of Basic Medical Sciences , 341-345.

Holiistic Online. (1998, 1 1). Diabetes. Retrieved June 16, 2009, from HolisticOnline.com: http://www.holisticonline.com/Remedies/Diabetes/diabetes_vitamins-and-supplements.htm

Jacobs, T. F., Evans, J. D., & Evans, E. W. (November 1, 2008). Role of Acetyl-L-Carnitine in the Treatment of Diabetic Peripheral Neuropathy. The Annals of Pharmacotherapy , Vol 42, 1686-1691.

Meyer, C., & Sekundo, W. (2005). Nutritional Supplementation to Prevent Cataract Formation. Nutrition and the Eye. Developmental Ophthalmol. , vol 38, pp 103-119.

Salvatore, A. (n.d.). Carnitine. Retrieved 6 16, 2009, from Office of Dietary Health- National Institute of Health: http://ods.od.nih.gov/factsheets/carnitine.asp

Seyoum B, S. E. (2008). Low levels of magnesium place diabetics at increased risk. Ethnicity and Disease , 147-151.

Yasuda, H., Sonobe, M., Yamashita, M., Terada, M., Hatanaka, L., Huitian, Z., et al. (July 1989). Effect of Prostaglandin E1 analogue TFC 612 on Diabetic Neuropathy in Streptozocin- Induced Diabetic Rats. Comparison with Aldose Reductase Inibitor ONO 2235. Diabetes , Vol 38, 832-838.

 

 

Sexual Dysfunction & Blood Sugar Control
Svati, Health Guide
8/10/09 10:38am

I've also heard that Chromium supplements are supposed to be very helpful in terms of lowering your blood sugars. Any thoughts?

8/21/09 9:45am

In my opinion Chromium picolinate is a supplement that needs further study becuase over the last 10 years in university classes, on the internet, and in many health and fitness magazines, I have seen countless articles either for or against additional supplementation of chromium for both diabetics and non-diabetics.

 In one study, I found an article in which a 28 year old woman who was diagnosed with Type 1 diabetes when she was 10, saw her glycosylated hemoglobin ( a1c) go down from 11.3% to 7.9% after taking chromium at a dose of 200 micrograms 3 times a day for three months. Other times I'll read studies where there was no improvement in diabetes management with chromium supplementation. Let me do some more reseach and get back to you with the most up to date research.

Thanks

 

Anonymous
David
8/20/09 10:50pm

Resveratrol is better for diabetics than any of these supplements.  Resveratrol lowers glucose levels and increases insulin sensitivity.

8/21/09 9:34am

Thanks for your response: The reason that I excluded resveratrol from this article is that the scope of the article was aimed towards type-1 diabetes management. The supplements I choose are ones that have many scientific studies proving their effectiveness. That's not to say that resveratrol or many other compounds might not have therapeutic benefits as well. I did find a lot of studies that proposed that resveratrol can be used to treat type 1 diabetes. Heres how:

 

Diabetes is an auto-immune disease in that the body has particular cells that destroy other cells. Killer T cells attack the insulin producing Beta-cells of the pancrease. In healthy people, these killer T cells will get eliminated at an early age during development or will be contained and tolerated in the peripheral lymphatic tissues. The mechanism for how these T cells become tolerized has been a mystery for many years. In one study, doctors reported that an enzyme, Sirt-1 (a type 3 histone deacetylase) is required for the T cell tolerance to take place. Genetic disruption of Sirt-1 activity leads to elevated immune repsonses and breakdown of the T cell peripheral tolerance. So, a Sirt-1 deficiency may enhance the development of diabetes. Resveratrol has been shown in studies to activate the Sirt-1 enzyme. Activation of the Sirt-1 by small molecules like resveratrol can potentially be used to treat type 1 diabetes by inhibiting the killer T calls from attacking the Beta cells of the pancrease. Currently, the team that performed these studies is following up on a patent application for the use of these Sirt-1 activators such as resveratrol for studies to be conducted on human subjects in the future.

 

Thanks again for your comment.

Andrew

 

 

Anonymous
Supplements
11/13/09 2:57am

good read. very helpful for diabetics

http://www.supplements.co.nz

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11/23/09 10:21pm

I really enjoyed your post on vitamins for diabetics. Very interesting about sorbitol, I had no idea!

I do have a question about the absorption of supplements in the body though, how much of these supplements are actually absorbed to make a difference? If your body cant absorb certain vitamins/minerals through food just how effective are these supplements, I have mixed feelings about them, I do take some supplements, and hope that they wont hurt my kidneys/liver.

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By Andrew Berry— Last Modified: 10/16/10, First Published: 08/06/09