Another diabetes myth just bit the dust: the idea that pre-meal (bolus) injections of regular human insulin should be given thirty minutes before eating. This is a myth that I grew up with, and one that I had religiously taught my insulin-using patients back in the days before insulin analogs became ...


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I think this is one of those things where A1C is not the ideal measure. I would be curious to see if a measure of variability within the day would show an advantage to the pre meal shot. The real issues would be if complications are a function of variability within similar long term averags A1cs.
I agree with Bennet. You can have a good A1c but fluctuating BG that I don't think is healthy.
What was the "blood glucose profile?" How often did they measure?
I agreee that using an A1C is not a good test as it only measures averages of the hemoglobin over a 2 to 3 month period. I think a better test would be to measure the post prandial glucose at one hour and two hour intervals to see if injecting regular insulin at 30 minutes preprandial or at the time one starts eating makes a difference. To me using the A1C is flawed.
On one note not having to wait or having to time the injection so it is 30 minutes before a meal could be a hug plus especially if one is eating out or eating at a friend's house and has to wait to eat.