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don't pee out the Mg
frankenduf
Wednesday, March 18, 2009 at 05:21 PM -
Can long term use damage kidney?
A.U.Arvindekar
Thursday, March 26, 2009 at 06:24 AMLoss of glucose from the urine could lead to a continued high concentration of glucose in the kidneys. would it lead to excessive glycation of kidney proteins and thereby damage of kidneys
re: Can long term use damage kidney?
Dr. Bill Quick
Thursday, March 26, 2009 at 07:16 AMYou identify one of zillions of conceivable issues with this new class of drugs; at this moment I have no idea, but it would seem likely that your question won't be answered until big studies are done that last a longer time, or perhaps until the drug has been on the market for several years.
Which, of course, is why the FDA and other regulatory authorities in other countries require large trials (called Phase III trials) that last at least a year before they will consider approving a drug for general use. And why they require continuing surveillance after they're approved.
Good question!
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interesting post- i found the Mg results the most intriguing- magnesium deficiency has been implicated in the etiology of insulin resistance- and the suspected process is via urinary losses- studies have shown that higher Mg intake can increase insulin sensitivity, but from this post idea, decreasing urinary losses of Mg might also work to increase insulin sensitivity- and i've also wondered if there's any link between chronic diuretic use and insulin resistance, via the same process of increased Mguria