DNA Testing for Type 2 Diabetes Risk Factor

David Mendosa Health Guide October 04, 2007
  • The first genetic test available to determine a risk factor for type 2 diabetes recently became available. I just beta tested and discussed it with the company’s CEO and several other officials. DNA Direct, a privately funded company in San Francisco, offers the test of this gene that can lead ...

6 Comments
  • Gretchen Becker
    Health Guide
    Oct. 05, 2007
    Very interesting, David. Did they tell you what this gene does?
    • Gretchen Becker
      Health Guide
      Oct. 05, 2007
      Hmm. Found one theory: "The mechanism(s) by which risk alleles in TCF7L2 increase risk of T2D most likely involve impairment of insulin secretion." Also, "Taken together, the data suggest an impaired incretin effect in carriers of the risk genotypes of TCF7L2." The latter might explain why Byetta worked so well for you.
    • David Mendosa
      Health Guide
      Oct. 05, 2007
      Dear Gretchen,

      Very interesting. I never thought of that, but you are so right that Byetta does work exceptionally well for me.
  • Anonymous
    Jenny
    Oct. 05, 2007

    The tests for the genes involved in MODY diabetes have been commercially available for several years years. I maintain a page about MODY and have heard from many people who have had these tests.  They are important because they often turn up the fact that people who have been diagnosed as having Type 2 or Type 1 were given the wrong diagnosis. Because...

    RHMLucky777

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    The tests for the genes involved in MODY diabetes have been commercially available for several years years. I maintain a page about MODY and have heard from many people who have had these tests.  They are important because they often turn up the fact that people who have been diagnosed as having Type 2 or Type 1 were given the wrong diagnosis. Because many doctors are ignorant about MODY many of us with MODY are improperly diagnosed to start with.

     

    Anyone with a family history of mixed diabetes diagnoses (both type 1 and type 2) or a family history of normal weight people diagnosed with Type 2, should consider these tests as they have important treatment implications.

     

    MODY forms of diabetes are often described as rare, they may not really be  rare, just underdiagnosed. The current estimate is that they explain 5% of all cases of diabetes. That's a lot of people given how many people have diabetes. 

     

     

  • robbo
    Oct. 05, 2007

    You made a comment:  "If I were planning on raising a family, this knowledge would be even more important. If I were married and if my wife also tested positive for the diabetes gene, we might think twice about having children."

     

    My parents had diabetes on both sides of the family.  They had 4 children, two of which, including your truly,...

    RHMLucky777

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    You made a comment:  "If I were planning on raising a family, this knowledge would be even more important. If I were married and if my wife also tested positive for the diabetes gene, we might think twice about having children."

     

    My parents had diabetes on both sides of the family.  They had 4 children, two of which, including your truly, have T1 diabetes.  I am glad they didn't have the test available, and didn't think twice!!

     

    Sometimes the risk is worth taking.  This message is not meant to be a FLAME, but I think I was worth the chance, even though I did end up having diabetes, and I hope you think you were worth it also, Dave. 

    • David Mendosa
      Health Guide
      Oct. 05, 2007
      Dear Robbo,

      I am glad that you are here! Me too!