Dr. Richard K. Bernstein knows how to cure diabetes, and researchers are ready to start the research. All they need is money. Does anyone have enough money and care enough about curing diabetes to fund this research? Do you?
Even if you have type 1 diabetes, you almost certainly still have some of your beta cells. If your body stops killing them, they will replicate and produce insulin -- and then you will possibly have a cure.
When I talked with Dr. Bernstein a few days ago, he told me that he knows how kill the specific killer T cells. Most famous as the leading proponent of a very low-carb diet, Dr. Bernstein is a diabetologist with a practice near New York City. He was also an engineer before he got in M.D. degree in his 40s.
The problem is that diabetes is an auto-immune disease. Our own immune system kills our beta cells. And it's not just type 1 that is an auto-immune disease.
"We have a lot of evidence that both type 1 and type 2 diabetes are autoimmune disorders," Dr. Bernstein told me. "And even aged type 1s upon autopsy are found to have some surviving beta cells that are capable of replication."
Our beta cells would replicate if we could kill the agents of our immune systems called "killer T cells." Many researchers are hard at work trying to figure out how to destroy them in hopes that they can thereby cure diabetes. Most well known is Denise Faustman, associate professor of medicine at Harvard University.
"She is assuming that a fairly broad class of killer t cells -- called CD8 -- includes the culprit killer t cell that is responsible for diabetes," Dr. Bernstein says. "She says in effect that if you wipe out all the CD8 cells, you'll catch the killer t cells responsible for diabetes."
But Dr. Faustman's approach is fraught with danger. "One problem with her technique of going after the whole category of killer t cells is that you render the patient immuno-incompetent," he says. "You are doing too much damage -- you are not doing focused damage."
I suggest that Dr. Faustman's technique would leave us susceptible to all sorts of infections. "Right," Dr. Bernstein replied. "And cancers."
Dr. Bernstein is sure that a more targeted approach would cure diabetes without leaving our bodies at greater risk of infections and cancers. About five years ago Professor Itamar Raz, who heads the diabetes unit of Israel's Hadassah University Hospital., cornered Dr. Bernstein.
They were at an informal dinner of a group of diabetologists. Dr. Raz told Dr. Bernstein that the only people who could give them any ideas were engineers. "He said, 'So maybe you can think about a cure for diabetes.'"
"I said, OK," Dr. Bernstein recalled. "It took me two days to come up with an idea."
His idea is a method for finding the killer t cells for type 1 diabetes, those for type 2, determining if they are the same or different, and if there are several types. "I have a method for finding out that's very simple, very straightforward," he told me. Then, when they find the appropriate killer t cells, they can either make an antibody against them or take a unique protein from them and vaccinate the people with it, just like with other diseases.