I have been using Byetta for three months and have lost 15 pounds.  Before the Byetta, I was a chronic couch potato, and was fatigued all the time.  I feel full with less food and stay satisfied longer.  I have more energy, have lower glucose levels, and lower blood pressure.  Next month, I am due for complete blood tests so I'll let you know the effect on A1C and cholestrol levels.  I am also interested to see if it lowers trigycerides.  My insurance company usually does not cover Byetta but will with a written request by my doctor.  The difference in the way I feel physically and mentally is well worth the cost of the drug and I hope to lose 50 more pounds by Christmas!!!  I have had some nausea but it's  been minor and usually occurs if I wait wait more than 90 minutes after the injection to eat.  Also, the injections are not the least bit painful.  They are easier than checking glucose levels.  It's been a God send for me.