The drug metformin is not recommended for people with
kidney disease. For this reason, some people think that metformin causes kidney disease. But new evidence
suggests that metformin might actually protect the kidneys.
For many people with type 2 diabetes , metformin is a very
effective drug. In everyone, the liver is a sort of "mother" organ. When blood
glucose (BG) levels go down, the liver releases some glucose into the blood to
make sure all the other organs get enough glucose energy to work properly.
When you eat and your BG levels start going up, the liver
is supposed to stop pushing all this glucose out into the bloodstream.
But for some reason, in people with type 2 diabetes, like
an oversolitous mother, the liver doesn't stop feeding the bloodstream after
meals. "Eat eat!" I can hear it say to a bloodstream already stuffed with
glucose. And this continued release of glucose into the bloodstream after
meals is one reason people with type 2 go high after me...
A recent report again reaffirms that metformin is the first medication to use when a patient with type 2 diabetes (T2D) needs help with lowering blood glucose levels. The 200+ page report, Oral Diabetes Medications for Adults With Type 2 Diabetes: An Update , was prepared for the Agency for Healthcare Research and Quality by the Johns Hopkins University Evidence-based Practice Center. It is loaded with tables and discussions, but the conclusion is strikingly brief: "Although the long-term benefits and harms of diabetes medications remain unclear, the evidence supports use of metformin as a firstline agent. Comparisons of two-drug combinations showed little to no difference in HbA1c reduction, but some combinations increased risk for hypoglycemia and other adverse events."
To summarize the findings from the report: An older diabetes drug, metformin, works better, and has fewer side effects than newer drugs for T2D. It's also cheaper, as it's been available as a generic for y...
Metformin as well as every other prescription drug has a "label" (in the US, called a "United States package insert" or USPI, and in Europe called the "Summary of Product Characteristics" or SPC). The label spells out what governmental agencies authorize drug companies to say about the good and bad of their prescription drugs. Labels vary from country to country depending on local laws, but the label seems always to contains a section concerning the use of the medication in pregnancy.
Drug companies and the regulators negotiate every word in a label for a new medication, as getting additional good information into the label is viewed as a marketing advantage (and vice versa for bad information). For older drugs such as metformin, which are available as generics and which are sold by several companies, there frequently is less financial incentive to update the label, and labeling may be similar or identical across all the generic versions of the drug.
Recently, the on-lin...
You should knowAnswers to your question are meant to provide general health information but should not replace medical advice you receive from a doctor. No answers should be viewed as a diagnosis or recommended treatment for a condition. Content posted by community members does not necessarily reflect the views of Remedy Health Media, which also reserves the right to remove material deemed inappropriate.