The drug metformin is not recommended for people with
kidney disease. For this reason, some people think that metformin causes kidney disease. But new evidence
suggests that metformin might actually protect the kidneys.
For many people with type 2 diabetes , metformin is a very
effective drug. In everyone, the liver is a sort of "mother" organ. When blood
glucose (BG) levels go down, the liver releases some glucose into the blood to
make sure all the other organs get enough glucose energy to work properly.
When you eat and your BG levels start going up, the liver
is supposed to stop pushing all this glucose out into the bloodstream.
But for some reason, in people with type 2 diabetes, like
an oversolitous mother, the liver doesn't stop feeding the bloodstream after
meals. "Eat eat!" I can hear it say to a bloodstream already stuffed with
glucose. And this continued release of glucose into the bloodstream after
meals is one reason people with type 2 go high after me...
I received an interesting question by e-mail recently, which brought up several good points to review. The author asked: "Can a patient use metformin after a heart attack (after 12 years of using metformin) assuming the patient has good renal function? My question is if metformin should be avoided forever after an acute myocardial infarction or just temporarily withheld after the heart attack in a patient with an adequate renal and liver function (also without congestive heart failure or hypersensitivity to metformin)." I answered: "According to the USPI (the "label") for Glucophage brand of metformin, GLUCOPHAGE and GLUCOPHAGE XR are contraindicated [should not be used] in patients with: Renal disease or renal dysfunction (e.g., as suggested by serum creatinine levels =1.5 mg/dL [males], =1.4 mg/dL [females] or abnormal creatinine clearance) which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction, and septicem...
The drug metformin is one of the most common drugs prescribed to treat type 2 diabetes. When you’re diagnosed, most physicians prescribe metformin as well as suggesting diet and exercise changes.
But not everyone can tolerate metformin. Some people get diarrhea and nausea, sometimes so severe they stop taking the drug. Starting the drug slowly and then increasing the dosage helps. Taking metformin with meals helps.
But sometimes that’s not enough and you decide to try something else.
Metformin should also not be used if you have impaired kidney function, because the kidney is where the drug is removed, and if your kidneys are impaired, the metformin concentrations might rise too high and cause a serious, sometimes life-threatening, complication called lactic acidosis.
Now a group of researchers have found that they can give metformin in a form that has the same benefits but doesn’t have the same side effects. What they do is coat the...
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