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Will taking anti-reflux drugs make you deficient in vitamin B 12 ? A recent article suggests that they could.
According to this research, patients who took PPIs (proton pump inhibitors) for more than 2 years had a 65% increase in vitamin B 12 deficiency. The H 2 inhibitors (for example, ranitidine [Zantac]) also increase risk but not as much as the PPIs.
This sounds scary. Vitamin B 12 deficiency can be serious.
But don’t panic and throw-out your antireflux drugs without investigating further.
They’re using a type of statistics that can magnify a small effect. For example, let’s say the risk of something in your age group is 2%. You have a 65% increased risk. That means your risk is 3.3%. Greater, yes, but still relatively low.
Metformin can also contribute to vitamin B 12 deficiency. This has been known since before I was diagnosed in 1996. In fact, the effect of the PPIs on B 12 deficiency has also been known for some time, as mentioned i...
Generic Name: CYANOCOBALAMIN - ORAL Pronounced: (SYE-an-oh-koe-BAL-a-min) Cyanocobalamin (Vitamin B-12) Oral Interactions
The effects of some drugs can change if you take other
drugs or herbal products at the same time. This can increase your risk for
serious side effects or may cause your medications not to work correctly. These
drug interactions are possible, but do not always occur. Your doctor or
pharmacist can often prevent or manage interactions by changing how you use
your medications or by close monitoring.
To help your doctor and pharmacist give you the best care,
be sure to tell your doctor and pharmacist about all the products you use
(including prescription drugs, nonprescription drugs, and herbal products)
before starting treatment with this product. While using this product, do not
start, stop, or change the dosage of any other medicines you are using without
your doctor's approval.
Some products that may interact with...
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