Can u-500 be fataly if swelling of stomach, legs, neck and jaws persist?

Hello My name is Felicia Munoz and I come from a diabetic mother and father.  I have been as diabetic for 21 years myself.  My question is regarding my father his most recent insulin change is this u-500 insulin.  His has swelling in his face; jaws and neck, under both of his arm pits he has swelling and hardness,  his stomach looks like his is about 13 monthe pregnant and it is very hard as well, his legs beneath his knees give him great pain and cramps.  His Drs. can't pin point the problem.  All of this has started since he was put on this u-500.  Can you please give me some advice or send me in the right direction??