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Have you ever heard of slow twitch and fast twitch muscle fibers? Muscles that are predominantly made up of fast twitch muscle fibers are our quick reacting, higher contractile force muscles that fatigue rather quickly. Muscles made up of predominantly slow twitch muscle fibers are our less explosive muscles that are much longer lasting than their counterpart. You often hear of these two types of muscle fibers when comparing track sprinters to marathon runners. It may seem strange to think of slow and fast twitch muscle fibers within the 4 layers of our pelvic floor muscles but they are there.
It is this combination of slow and fast twitch muscle fibers that requires us to work, not only the quick flicks or quick contractions of the sphincter muscles of our pelvic floor, but also the steady, endurance of the levator ani muscles.
Let's take a quick review of the layers of the pelvic floor. The outermost layer is our anal sphincter. The contraction of this muscle is the easiest to...
I received an interesting question by e-mail recently, which brought up several good points to review. The author asked: "Can a patient use metformin after a heart attack (after 12 years of using metformin) assuming the patient has good renal function? My question is if metformin should be avoided forever after an acute myocardial infarction or just temporarily withheld after the heart attack in a patient with an adequate renal and liver function (also without congestive heart failure or hypersensitivity to metformin)." I answered: "According to the USPI (the "label") for Glucophage brand of metformin, GLUCOPHAGE and GLUCOPHAGE XR are contraindicated [should not be used] in patients with: Renal disease or renal dysfunction (e.g., as suggested by serum creatinine levels =1.5 mg/dL [males], =1.4 mg/dL [females] or abnormal creatinine clearance) which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction, and septicem...
Generic Name: GLYBURIDE/METFORMIN TABLET - ORAL Pronounced: (GLEYE-byou-ride/met-FOR-min) Glyburide-Metformin Oral Overdose
If overdose is suspected, contact your local poison
control center or emergency room immediately. US residents can call the US
National Poison Hotline at 1-800-222-1222. Canada residents can call a
provincial poison control center. Overdose can cause lactic acidosis and low
blood sugar. Symptoms of overdose may include: rapid breathing, severe
drowsiness, slow/irregular heartbeat.
Glyburide-Metformin Oral Missed Dose
If you miss a dose, take it as soon as you remember. If it
is near the time of the next dose, skip the missed dose and resume your usual
dosing schedule. Do not double the dose to catch up.
Glyburide-Metformin Oral Notes
Do not share this medication with others.
You should attend a diabetes education program to learn
more about diabetes and all the important aspects of its treatment, including
You should know
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