I have manic depression and prediabetes and just started Metformin 500 mg once a day. I went into a hypomanic episode and have had to have my anti-depressant decreased. Has anyone had this effect?
That didn't happen to me when I started taking Metformin 500mg twice a day, but I can see how it could. Diabetes and prediabetes can cause depressive symptoms that could affect how well your antidepressant was able to work. Then once your blood sugar was controlled, the amount of antidepressant you were taking was no longer fighting the symptoms caused by your prediabetes and so it turned out to be too high a dose.
I've just written a SharePost about my own experience: My Misdiagnosed Major Depressive Episode. My experience parallels yours at a lower mood level.
Yes. It's true. There is a limit to the mg and also if you don't space them out exactly 12 hours apart, it will also happen.