A classic cost/benefit analysis- there are benefits in drinking wine (cardioprotective), but risks as well (stress on the liver).  I agree that in general, ETOH lowers sugar, so make sure you don't drop too low after dinner, although this is unlikely since you're eating food with the ETOH.  The other concern is with lactic acidosis and metformin.  So if you have liver or kidney insufficiency, the risk of ETOH may outweigh the benefit. The reason doctors never tell anyone to drink booze is that they don't know if you have the discipline to limit yourself to 1 drink.  Since I drink 1 glass red wine with dinner, I am biased, but here's my advice: Since you enjoy a good glass of wine, and since life should be lived to the fullest, I would not give up the wine with the following provisos: 1- drink with a meal to avoid going too low; 2- make sure your doctor monitors your liver and kidney function periodically (simple blood tests- LFTs and BUN/Cr); 3- never binge drink- 1 glass of wine should be enough for temporal happiness :) Good luck, and remember- Jesus turned the water to wine for a reason (although metformin wasn't around back then...