Some adverse effect that have been attributed to Actos are cold-like symptoms, headache, sinus infection, muscle pain, tooth disorder and sore throat. In my opinion, these tend to be generic adverse events that occur in most drugs trials, but the pharm company is required by law to report them. Understandably it could be any number of things.  Definately keep a close eye on it, and tell your doctor what you observe.  The problem is that Actos takes anywhere from 4-6 weeks to get working, and when you cease taking Actos, due to gene transcription, it's effects can still be seen for up to 6 months.  So, if it is the Actos that is causing the coughing and wheezing, it might not necessarily stop right after discontinueing the medication.  Actos is the most studied and arguably the most well rounded type 2 diabetes drug on the market today.  Although, it is not for everyone; it can be extremely helpful in your longterm battle against type 2 diabetes.  My only advice is to be vigilant and tell your doctor of any changes. Take care.