A few days ago I was browsing through an old physiology textbook, the one I used when I was in college, because I was curious to read what they said about diabetes way back then.
The book, Textbook of Medical Physiology, second edition, by Arthur Guyton, was copyright in 1956, more than 50 years ago. And I came across this statement:
"In the early days of treating diabetes it was the tendency to reduce the carbohydrates in the diet so that the insulin requirements would be minimized. This procedure kept the blood sugar level down to normal values and prevented the loss of glucose in the urine, but it did not prevent the abnormalities of fat metabolism. Actually, it exacerbated these. Consequently, there is a tendency at present to allow the patient a normal carbohydrate diet and then to give simultaneously large quantities of insulin to metabolize the carbohydrates. This depresses the rate of fat metabolism and also depresses the high level of blood cholesterol which occurs in diabete...
An insulin testis a blood test that measures the amount of insulin, a hormone that regulates blood sugar.
How the test is performed
Blood is drawn from a vein on the inside of the elbow or the back of the hand. The puncture site is cleaned with antiseptic, and an elastic band is placed around the upper arm to apply pressure and restrict blood flow through the vein. This causes veins below the band to fill with blood.
A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. After the blood is drawn, the band is removed to restore circulation. Then, the needle is removed, and the puncture site is covered to stop any bleeding.
For an infant or young child:
The area is cleansed with antiseptic and punctured with a sharp needle or a lancet. The blood may be collected in a pipette (small glass tube), on a slide, onto a test strip, or into a small container. Cotton or a bandage may be applied to the puncture site i...
Normally, there are no antibodies against insulin in your blood.
Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
What abnormal results mean
If you have IgG and IgM antibodies against insulin, your body reacts as if the insulin is foreign. This may make insulin less effective, or not effective at all.
The antibodies can also change the amount of time it takes insulin to work, putting you at risk for low blood sugar. This means that the insulin cannot move glucose from the bloodstream into the cells. As a result, increased levels of insulin are needed to have the same effect, which is called insulin resistance.
If the test shows high levels of IgE antibody against insulin, your body has developed an allergic response to the medication. This could put you at risk for skin reactions, or more severe reactions. Other medications, such as antihistamines or low-dose i...
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