Many of us think that using insulin before it’s necessary will help to “rest” our beta cells so they’ll last longer.
But now comes a research paper showing that excess insulin actually causes diabetes in nondiabetic mice fed a chow diet. The chow diet is the normal diet given to mice unless you want to fatten them up and give them diabetes, in which case you feed them a high-fat, high-carbohydrate diet.
The high insulin levels were caused by injecting these normal mice with insulin glargine (Lantus). This injected insulin did not seem to cause hypoglycemia, although the researchers measured only fasting blood glucose (BG) levels and watched for signs of severe hypoglycemia.
The injected insulin did cause insulin resistance, as might be expected as it’s common for mammals to develop resistance to hormones whose levels are high. Most of the increased insulin resistance was in the liver. But instead of “resting” the beta cell...
High carbohydrate diet? Low carbohydrate or no carbohydrate
diet? Low Fat diet?
Mediterranean diet? South Beach
diet? There are so many choices and different ways to manage food. What is the
fuss about carbohydrates? What role do carbs play in the body?
In the presence of insulin, carbohydrates are funneled
through a complex metabolic pathway called glycolysis, which ultimately
provides energy for your body. Think of insulin as one of the keys that helps
to unlock carbohydrate breakdown and provide energy for daily activities.
Carbohydrates are necessary for survival. Without carbohydrates in our diet,
other sources of energy such as fat and protein are broken down, but these
provide less energy to your body overall. If your body only uses fats for
energy or insulin isn't around to help with carbohydrate breakdown, you could
possibly develop byproducts of fat metabolism or ketones. These chemicals can
build up in your bloodstream and lead to the possibility of high acid levels,...
A few days ago I was browsing through an old physiology textbook, the one I used when I was in college, because I was curious to read what they said about diabetes way back then.
The book, Textbook of Medical Physiology, second edition, by Arthur Guyton, was copyright in 1956, more than 50 years ago. And I came across this statement:
"In the early days of treating diabetes it was the tendency to reduce the carbohydrates in the diet so that the insulin requirements would be minimized. This procedure kept the blood sugar level down to normal values and prevented the loss of glucose in the urine, but it did not prevent the abnormalities of fat metabolism. Actually, it exacerbated these. Consequently, there is a tendency at present to allow the patient a normal carbohydrate diet and then to give simultaneously large quantities of insulin to metabolize the carbohydrates. This depresses the rate of fat metabolism and also depresses the high level of blood cholesterol which occurs in diabete...
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