Many of us think that using insulin before it’s necessary will help to “rest” our beta cells so they’ll last longer.
But now comes a research paper showing that excess insulin actually causes diabetes in nondiabetic mice fed a chow diet. The chow diet is the normal diet given to mice unless you want to fatten them up and give them diabetes, in which case you feed them a high-fat, high-carbohydrate diet.
The high insulin levels were caused by injecting these normal mice with insulin glargine (Lantus). This injected insulin did not seem to cause hypoglycemia, although the researchers measured only fasting blood glucose (BG) levels and watched for signs of severe hypoglycemia.
The injected insulin did cause insulin resistance, as might be expected as it’s common for mammals to develop resistance to hormones whose levels are high. Most of the increased insulin resistance was in the liver. But instead of “resting” the beta cell...
Low-carb advocates are already jumping all over the American Diabetes Association for the new "Nutrition Recommendations" that the organization published yesterday. That policy statement, published in a supplement to the January 2008 issue of Diabetes Care , provides only limited endorsement of a low-carb diet. It's good only for weight loss and only effective for up to a year, they maintain. The full-text of the statement is not yet free online. But Dr. Bill Quick, my friend and colleague here at Health Central, subscribes to Diabetes Care and sent me an electronic copy. "I am underwhelmed," writes Dr. Mary Vernon. "I am most saddened by the lack of understanding. Carbohydrate restriction and the resulting control of insulin secretion is much more than weight loss. It's not the weight -- it's the metabolic state your body is in that generates disease or well-being." "it makes you wonder how much longer they will drag their feet before realizing low-carb is about so much more than...
Normally, there are no antibodies against insulin in your blood.
Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
What abnormal results mean
If you have IgG and IgM antibodies against insulin, your body reacts as if the insulin is foreign. This may make insulin less effective, or not effective at all.
The antibodies can also change the amount of time it takes insulin to work, putting you at risk for low blood sugar. This means that the insulin cannot move glucose from the bloodstream into the cells. As a result, increased levels of insulin are needed to have the same effect, which is called insulin resistance.
If the test shows high levels of IgE antibody against insulin, your body has developed an allergic response to the medication. This could put you at risk for skin reactions, or more severe reactions. Other medications, such as antihistamines or low-dose i...
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