FROM OUR EXPERTS
Many of us think that using insulin before it’s necessary will help to “rest” our beta cells so they’ll last longer.
But now comes a research paper showing that excess insulin actually causes diabetes in nondiabetic mice fed a chow diet. The chow diet is the normal diet given to mice unless you want to fatten them up and give them diabetes, in which case you feed them a high-fat, high-carbohydrate diet.
The high insulin levels were caused by injecting these normal mice with insulin glargine (Lantus). This injected insulin did not seem to cause hypoglycemia, although the researchers measured only fasting blood glucose (BG) levels and watched for signs of severe hypoglycemia.
The injected insulin did cause insulin resistance, as might be expected as it’s common for mammals to develop resistance to hormones whose levels are high. Most of the increased insulin resistance was in the liver. But instead of “resting” the beta cell...
High carbohydrate diet? Low carbohydrate or no carbohydrate
diet? Low Fat diet?
Mediterranean diet? South Beach
diet? There are so many choices and different ways to manage food. What is the
fuss about carbohydrates? What role do carbs play in the body?
In the presence of insulin, carbohydrates are funneled
through a complex metabolic pathway called glycolysis, which ultimately
provides energy for your body. Think of insulin as one of the keys that helps
to unlock carbohydrate breakdown and provide energy for daily activities.
Carbohydrates are necessary for survival. Without carbohydrates in our diet,
other sources of energy such as fat and protein are broken down, but these
provide less energy to your body overall. If your body only uses fats for
energy or insulin isn't around to help with carbohydrate breakdown, you could
possibly develop byproducts of fat metabolism or ketones. These chemicals can
build up in your bloodstream and lead to the possibility of high acid levels,...
Normally, there are no antibodies against insulin in your blood.
Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
What abnormal results mean
If you have IgG and IgM antibodies against insulin, your body reacts as if the insulin is foreign. This may make insulin less effective, or not effective at all.
The antibodies can also change the amount of time it takes insulin to work, putting you at risk for low blood sugar. This means that the insulin cannot move glucose from the bloodstream into the cells. As a result, increased levels of insulin are needed to have the same effect, which is called insulin resistance.
If the test shows high levels of IgE antibody against insulin, your body has developed an allergic response to the medication. This could put you at risk for skin reactions, or more severe reactions. Other medications, such as antihistamines or low-dose i...
You should know
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