Over time, many patients with type 2 diabetes experience progressive beta-cell dysfunction and will require insulin therapy, either alone or in combination with oral medications, for better glycemic control.
Type 2 diabetes is defined as having insulin resistance (IR). At least in the early stages of the disease, you’re producing plenty of insulin, but because of the IR, the insulin doesn’t work very well. (Type 1 diabetes is an autoimmune disease and results in insulin deficiency.) Thus one would think that any treatment that reduced IR would…