Common Questions to Diabetic Nerve Pain Answered
There are several forms of nerve damage (or in doctor-speak, neuropathy). The form that most people with diabetes (PWD) have is damage to the nerves that provide sensation from the far ends of the body, particularly the feet; this form is called distal sensory neuropathy or peripheral neuropathy.
The painful sensations (called dysesthesias or parathesias) that are associated with diabetic peripheral neuropathy may disappear over time. Sometimes this is due to improvement in diabetes control; sometimes it's due to medications that block the pain. True reversal of the damage to the nerves seems unlikely, and people who report that their pain is gone may have had further deterioration of the function of the affected nerves.
One variety of diabetic neuropathy, called diabetic mononeuropathy (damage to a single nerve) can affect any nerve. The most common cause of thigh numbness without other symptoms is compression or irritation of a nerve called the lateral femoral cutaneous nerve that supplies the skin of the upper outer thigh.
The mechanism of developing diabetic neuropathy is not clear. One thought is that diabetic neuropathy results from injury involving the small blood vessels that supply nerves. Others have speculated that increases in stuff called advanced glycated end products, or of protein kinase C, or stuff from other metabolic pathways, are involved.
Yes, peripheral neuropathy is described in the U.S. Product Insert for Zocor (simvastatin) --along with a zillion other events that have been reported. However, I'd be worried that the problem you are discussing might be a different one: myopathy (muscle damage) which can cause muscle pain, tenderness or weakness.
Many physicians have seen and treated cases of diabetic neuropathy, and would be able to advise you as to whether you have it, and to run tests to diagnose it if needed, and advise you as to how to treat it.