Metformin (generic) or Glucophage (brand) has become a very popular therapeutic agent in multiple medical conditions. According to David McCulloch (UpToDate 19.3- January, 2012) two classes of oral hypoglycemic medications directly improve insulin action: biguanides (metformin) and thiazolodinediones. Metformin is widely considered to be the first choice for oral therapy of type 2 diabetes based on the 2006 (and updated in 2009) consensus statement from the American Diabetes Association and the...

