Prior to 2001, there were only three basal insulins that were used in combination with either regular or rapid acting insulin. NPH and Lente were intermediate acting insulin (duration 10-12 hours) along with Ultralente (duration 24-36 hours). These basal insulins had peaks that could increase the risk of hypoglycemia. Presently, only NPH is available and is generally used with regular or rapid acting insulin in conventional split mixed insulin regimens of two or three shots per day. The main...