This medication is a combination of two drugs, rosiglitazone and glimepiride. It is used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes (non-insulin-dependent diabetes). Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.
You should only begin taking rosiglitazone/glimepiride when other drugs have not worked well or cannot be taken, and you do not wish to take pioglitazone-containing medications. If you are currently taking rosiglitazone/glimepiride and have good control of your blood sugars and no new side effects/symptoms, continue to take this medication as directed. Ask your doctor promptly about the risks and benefits of this medication, since a small number of people have had serious side effects (see Warning Section).
After November 18, 2011, only patients enrolled in the Avandia-Rosiglitazone Medicines Access Program may obtain and use rosiglitazone-containing products. Your doctor will need to register you with this program before you can receive your prescription. Only physicians enrolled in the Avandia-Rosiglitazone Medicines Access Program may prescribe rosiglitazone-containing products, and only certified mail-order pharmacies enrolled in the program may dispense them. Talk to your doctor or pharmacist for more details about the program.
Rosiglitazone belongs to a class of drugs known as thiazolidinediones or "glitazones". It works by helping to restore your body's proper response to insulin, thereby lowering your blood sugar.
Glimepiride belongs to a class of drugs known as sulfonylureas. It works by stimulating the release of your body's natural insulin.