This product contains 2 medications: sitagliptin and simvastatin. Sitagliptin is used with a proper diet and exercise program to control high blood sugar in people with type 2 (non-insulin-dependent) diabetes. Sitagliptin works by increasing levels of natural substances called incretins. Incretins help to control blood sugar by increasing insulin release, especially after a meal. They also decrease the amount of sugar your liver makes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.
Sitagliptin should not be used to treat people with type 1 diabetes (insulin-dependent diabetes).
Simvastatin is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It belongs to a group of drugs known as "statins." It works by reducing the amount of cholesterol made by the liver. Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks.
In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help this medication work better include exercising, losing weight if overweight, and stopping smoking. Consult your doctor for more details.
How To Use
Read the Medication Guide provided by your pharmacist before you start using sitagliptin/simvastatin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually once daily in the evening. Swallow the tablets whole. Do not split, crush, or chew the tablets.
The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.
Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.
Take this medication regularly to get the most benefit from it. Remember to take it at the same time each day. It is important to continue taking this medication even if you feel well.
It is very important to continue to follow your doctor's advice about diet and exercise. For the treatment of high cholesterol/triglycerides, it may take up to 4 weeks before you get the full benefit of this drug.
Tell your doctor if your condition does not improve or if it worsens (such as blood sugar levels remaining high or increasing).