Generic Name: ROSIGLITAZONE/GLIMEPIRIDE - ORAL
Pronounced: (row-sih-GLIH-ta-zone/glih-MEH-pih-ride)

Avandaryl Oral Precautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to rosiglitazone or glimepiride; or to other "glitazones" (e.g., pioglitazone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Promptly talk with your doctor or pharmacist about the benefits and possible risks of this medication, even if you have been taking it for awhile, especially if you have heart problems. Do not stop taking it unless directed to do so.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

• type 1 diabetes (insulin-dependent diabetes)
• very high blood sugar levels (diabetic ketoacidosis)
• newly diagnosed or worsening heart failure (acute congestive heart failure)
• history of liver disease
• active liver disease

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

• heart problems (e.g., chronic congestive heart failure, heart attack, angina)
• fluid in your lungs
• swelling (edema, fluid retention)
• kidney disease
• thyroid problems
• certain hormonal conditions (adrenal/pituitary insufficiency, SIADH-syndrome of inappropriate secretion of antidiuretic hormone)
• mineral imbalance (hyponatremia)
• anemia
• high blood cholesterol
• eye (retina) problems
• bone problems (e.g., osteoporosis, osteopenia)

You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar levels. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

Limit alcohol while taking this medication because it can increase your risk of developing low blood sugar (hypoglycemia).

During times of stress, such as fever, infection, injury or surgery, it may be more difficult to control your blood sugar. Consult your doctor because a change in your medication may be required.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

This medication may increase the risk of bone fracture (upper arm, hand, foot) in female patients. To lower the chance of getting injured, use caution when doing activities such as contact sports.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, the elderly may be at greater risk for hypoglycemia while using this drug.

This medication can cause changes in the menstrual cycle (promote ovulation) in women with certain fertility problems. Consult your doctor or pharmacist about the use of reliable birth control while taking this medication.

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