Vitamin E Dangerous?

Posting Date: 11/10/2004

The 19 studies took place between 1993 and 2004 and involved more than 136,000 patients in North America, Europe and China. All of the studies involved use of a control group taking a dummy pill, or placebo. Risk of death was estimated by comparing the death rates in both groups. Follow-up periods ranged from 1.4 years to 8.2 years.

When the data for these trials was re-evaluated, through a process called a meta-analysis, nine of 11 trials involving high-dose vitamin E (400 IU per day, or more) showed an increased risk of death. The other eight trials involved low-dose vitamin E users.

It was unclear whether low amounts (200 IU per day or less) of vitamin E supplements increased a person?s risk of death.

Because most of the patients in all of the trials were over 60, and a majority had pre-existing conditions, such as heart disease, the study?s application to younger, healthy adults may be limited, the Hopkins researchers point out.

Current United States dietary guidelines do not recommend vitamin E supplementation; however, the guidelines do set an upper tolerable intake limit of up to 1,500 IU per day.

?Policy makers and government regulators should consider lowering this level, perhaps, to an upper limit of 400 IU per day,? said Eliseo Guallar, M.D., Dr.P.H., senior author of the study and assistant professor of epidemiology at the Bloomberg School of Public Health.

?Additional research is needed to determine the effects, if any, of low-dose levels of vitamin E supplements. As well, there are unresolved questions on the benefits of vitamin E when combined with other antioxidants.?

Vitamin E is one of 13 vitamins essential to body metabolism, cell growth and function. It is also known as tocopherol and is an antioxidant important in the formation of red blood cells and the use of vitamin-K-mediated clotting factors. Sources of dietary intake include wheat germ, corn, nuts, seeds, olives, spinach, asparagus and other green leafy vegetables, vegetable oils, and products made from vegetable oils, such as margarine. On average, dietary intake of vitamin E is 10 IU per day. Multivitamin pills usually contain 30 IU to 60 IU of

vitamin E.

The research was conducted at Johns Hopkins. Other researchers who participated in this study were Roberto Pastor-Barriuso, Ph.D., Darshan Dalal, M.D., M.P.H.; Rudolph Riemersma, Ph.D; and Lawrence Appel, M.D., M.P.H.

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