Paget's Disease: ACTONEL is indicated for treatment of Paget's disease of bone (osteitis deformans). Treatment is indicated in patients with Paget's disease of bone (1) who have a level of serum alkaline phosphatase at least 2 times the upper limit of normal, or (2) who are symptomatic, or (3) who are at risk for future complications from their disease, to induce remission (normalization of serum alkaline phosphatase). DOSAGE AND ADMINISTRATION ACTONEL should be taken at least 30 minutes before the first food or drink of the day other than water. To facilitate delivery to the stomach, ACTONEL should be swallowed while the patient is in an upright position and with a full glass of plain water (6 to 8 oz). Patients should not lie down for 30 minutes after taking the medication (see PRECAUTIONS, General). Patients should receive supplemental calcium and vitamin D if dietary intake is inadequate (see PRECAUTIONS, General). Calcium supplements and calcium-, aluminum-, and magnesium-containing medications may interfere with the absorption of ACTONEL and should be taken at a different time of the day. ACTONEL is not recommended for use in patients with severe renal impairment (creatinine clearance <30 mL/ min). No dosage adjustment is necessary in patients with a creatinine clearance Treatment of Postmenopausal Osteoporosis (see INDICATIONS AND USAGE): The recommended regimen is: one 5-mg tablet orally, taken daily or one 35-mg tablet orally, taken once a week Prevention of Postmenopausal Osteoporosis (see INDICATIONS AND USAGE): The recommended regimen is one 5-mg tablet orally, taken daily Alternatively, one 35-mg tablet orally, taken once a week may be considered Treatment and Prevention of Glucocorticoid-Induced Osteoporosis (see INDICATIONS AND USAGE): The recommended regimen is: one 5-mg tablet orally, taken daily | ||||
Email this article
Printer friendly
Bookmark this pageadvertisement
